Small:NIR-II Enhanced treatment of drug-resistant bacterial infections with light responsive cu2mos  4 nanoenzyme

The drug resistance of

is becoming more more serious which is a serious threat to human health. Due to the lack of effective treatment about 700000 people die of drug-resistant bacteria infection every year in the world. At present there are many difficulties in the research development of new antibiotics so it is urgent to develop new strategies to effectively eliminate drug-resistant bacteria. In recent years catalytic sterilization based on nano enzyme has been considered as a promising antibacterial strategy. Nanozymes can kill bacteria by catalyzing the production of reactive oxygen species (ROS) other unique mechanisms also have good bactericidal effect on drug-resistant bacteria. However the low catalytic activity of nanoenzymes limits their antibacterial properties applications. Therefore it is a feasible way to further improve the catalytic activity by using other properties of nano enzyme.

Professor Wang Lianhui Associate Professor Yu wenlihui (co corresponding author) of Institute of information materials nanotechnology Nanjing University of Posts telecommunications developed an antibacterial strategy of nir-ii photothermal enhanced catalysis to produce ROS around the scientific problem that the low catalytic efficiency of nanoenzyme limits its antibacterial performance The title "catalytic activity for efficient application of multidrug resistant bacteria" was published in the international well-known journal small

. The research team prepared small-size cu2mos4 nanosheets by hydrothermal synthesis combined with mechanical stripping found that the material had good oxidase / peroxidase like activity excellent nir-ii photothermal properties. Under the irradiation of nir-ii laser the enzyme like catalytic activity of cu2mos4 nanosheets can be further enhanced. The results of antibacterial experiment in vitro showed that the inactivation rate of cu2mos4 nanoenzyme (40 μ g / ml) against drug-resistant Escherichia coli under the irradiation of nir-ii laser (1064 nm 1 W / cm2) was up to 8 orders of magnitude its antibacterial effect was significantly better than that of common nanoenzymes. In the mouse infection model cu2mos4 nanoenzyme can effectively treat the subcutaneous abscess infected by drug-resistant staphylococcus aureus under the irradiation of nir-ii laser can promote the recovery of infected tissue. In addition the biocompatibility of cuos4 nanoparticles in vitro in vivo was good. Therefore cu2mos4 nanoenzyme is expected to be used as a highly effective nano antibacterial agent for the treatment of drug-resistant bacterial infections.

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